Long-Acting Insulin-Like Growth Factor Analog
Buy IGF-1 LR3
Not For Human Use, Lab Use Only.
Modified IGF-1 with 3-4x longer half-life than native IGF-1. Drives muscle protein synthesis and satellite cell activation through direct IGF-1 receptor binding — without GH intermediary.
≥98% Purity
HPLC Verified
Research Grade
Lyophilized
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Specifications
IGF-1 LR3 — Co-Administered Peptides
CJC-1295 / Ipamorelin
CJC/Ipamorelin elevates endogenous GH and downstream IGF-1. Adding exogenous IGF-1 LR3 provides a prolonged, direct IGF-1 signal — the two approaches work through the same downstream receptor but different upstream routes.
TB-500
IGF-1 LR3 drives anabolic muscle growth; TB-500 supports the connective tissue and anti-inflammatory environment needed to sustain high-volume training. Complementary in muscle repair research models.
IGF-1 LR3 — Biological Mechanism
Direct IGF-1 Receptor Binding
IGF-1 LR3 binds directly to IGF-1 receptors on muscle, bone, and other tissues — activating PI3K/Akt and MAPK/ERK pathways that drive cell growth, protein synthesis, and differentiation. Unlike GH secretagogues, it bypasses the GH → liver → IGF-1 axis entirely.
Reduced IGF Binding Protein Affinity
Native IGF-1 is rapidly cleared by IGF binding proteins (IGFBPs), particularly IGFBP-3. The LR3 modification (Arg substitution at position 3, plus N-terminal 13-amino-acid extension) dramatically reduces IGFBP binding — extending the half-life from ~6 hours to ~20–30 hours and increasing receptor exposure time.
Muscle Satellite Cell Activation
IGF-1 LR3 activates muscle satellite cells (muscle stem cells), which differentiate into myotubes and fuse with existing muscle fibers — increasing muscle fiber number and size. This myogenic effect is particularly significant in resistance training research models.
Buying IGF-1 LR3: Laboratory Handling Notes
Illustrative ranges from published laboratory work—reference only, not a protocol for use.
Post-Training Injection
20–100 mcg/day
Once daily, post-exercise
Post-exercise timing maximizes receptor sensitivity. Inject into or near trained muscle group. Long half-life means a single daily injection maintains elevated IGF-1 levels throughout the day.
IGF-1 LR3 — Vial-Specific Reconstitution
1mg vial + 1mL BAC water = 1,000 mcg/mL. For a 40–60 mcg daily dose draw 0.04–0.06mL on an insulin syringe.
IGF-1 LR3 is acid-stable and dissolves readily. Refrigerate at 2–8°C post-reconstitution; use within 3–4 weeks (slightly shorter than most peptides due to IGF-1 instability in neutral pH).
IGF-1 LR3 — Important Notice
This page summarizes identity, purity, and handling context for catalog navigation. It is not medical advice, a drug label, or a summary of clinical outcomes for any use. Materials are sold for legitimate laboratory research only; verify requirements with your institution and the supplier.
Peptides to Buy With IGF-1 LR3
Thymosin Alpha-1
Acetyl 28-amino-acid thymic peptide. ≥98% HPLC purity verified.
CAS: 62304-98-7
Thymulin
Zinc-binding nonapeptide thymic hormone. ≥98% HPLC purity verified.
CAS: 63958-90-7
IGF-1 LR3
from $71.99