Pineal Tetrapeptide — Telomere & Longevity Research
Buy Epitalon 10mg
Synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on the natural pineal peptide epithalamin. 30+ years of research by Khavinson et al. — telomerase activation, anti-aging, and melatonin restoration.
≥98% Purity
HPLC Verified
Research Grade
Lyophilized
Fast Shipping
Free $200+
Specifications
Mechanism of Action
Telomerase Activation
Khavinson's landmark research showed Epithalon stimulates telomerase (hTERT) expression in human fetal fibroblasts — allowing cells to extend their telomeres and replicate beyond the normal Hayflick limit without malignant transformation. This is the primary proposed mechanism for its life-extension effects.
Pineal Gland Restoration & Melatonin
Epithalon stimulates melatonin synthesis in the pineal gland. Pineal function and melatonin production decline significantly with age. Restoration of melatonin pulsatility improves circadian rhythm regulation, sleep architecture, and immune function.
Antioxidant & Anti-Inflammatory Activity
Epithalon exhibits free radical scavenging activity and upregulates antioxidant enzymes including SOD and catalase. Reduces oxidative stress — a primary driver of cellular aging — at both the nuclear and mitochondrial level.
Research Findings
Telomerase & Cellular Longevity
Khavinson et al. demonstrated telomerase activation and extended replicative capacity in treated fibroblasts vs controls. No malignant transformation was observed — the key safety distinction from oncogenic telomerase activation.
Khavinson et al., Bull Exp Biol Med (2003); Peptides (2002)
Animal Lifespan Extension
Rodent studies showed 8–13% increase in mean lifespan with Epithalon treatment. Drosophila studies showed up to 36% lifespan extension. Spontaneous tumor incidence was reduced in treated animals.
Khavinson & Morozov, Ann NY Acad Sci (2003)
Preclinical Safety Data
Epithalon has been studied in human clinical trials (small scale) with no significant adverse effects reported. No mutagenicity, carcinogenicity, or teratogenicity in preclinical studies. No malignant transformation observed even with telomerase activation — a critical safety distinction.
Research Dosing Protocols
From published literature — for research reference only.
Subcutaneous Injection
5–10 mg/day
Once daily for 10–20 day course, 2–3x/year
Most studied protocol follows a 'course' model rather than continuous dosing.
Reconstitution Guide
- 1
Add 1–2 mL bacteriostatic water to the 50mg vial.
- 2
50mg + 2mL = 25mg/mL. For a 5mg dose, draw 0.2mL.
- 3
Swirl gently. Refrigerate at 4°C. Use within 4 weeks.
Stacking Guide
GHK-Cu
$50.00Epithalon addresses cellular aging at the telomere level; GHK-Cu addresses tissue aging at the collagen and gene-expression level. Together they form a multi-mechanism longevity research stack.
Frequently Asked Questions
What is Epithalon?
Epithalon (Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed by Vladimir Khavinson at the St. Petersburg Institute of Bioregulation. It is based on Epithalamin, a natural extract from bovine pineal glands. Studied primarily for telomerase activation, anti-aging, and melatonin restoration.
What is the Khavinson research?
Dr. Vladimir Khavinson conducted 30+ years of research on pineal peptides at the St. Petersburg Institute. Key findings include telomerase activation in human fibroblasts, extended cellular replicative capacity, lifespan extension in multiple animal models, and improved melatonin synthesis in aged subjects.
Research Disclosure: All products on this page are for laboratory research purposes only. They are not FDA-approved for human consumption, injection, or therapeutic use. Research findings cited are from preclinical and clinical studies and should not be interpreted as medical advice. Always consult a licensed healthcare provider.
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