Anti-Wrinkle Octapeptide — SNAP-8
Buy SNAP-8 10mg
Synthetic 8-amino-acid peptide that reduces neuromuscular transmission at the dermal-muscular junction — diminishing expression lines by relaxing facial muscle contraction. Evidence-based topical anti-wrinkle research compound.
≥98% Purity
HPLC Verified
Research Grade
Lyophilized
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Specifications
Mechanism of Action
SNARE Complex Inhibition
SNAP-8 is a synthetic analog of the N-terminal fragment of SNAP-25, a protein essential for the SNARE complex that mediates neurotransmitter (acetylcholine) vesicle fusion at the neuromuscular junction. By competing with SNAP-25, SNAP-8 partially inhibits vesicle fusion and reduces acetylcholine release — relaxing muscle contraction.
Expression Line Reduction
Reduced muscle contraction at facial expression points (glabella, forehead, crow's feet, nasolabial fold) decreases the mechanical stress that deepens expression lines over time. Applied topically in cosmetic formulations, SNAP-8 provides a non-injectable analog to botulinum toxin's mechanism.
Research Findings
Clinical Wrinkle Reduction
In vitro neuronal contraction studies show SNAP-8 reduces the amplitude of muscle contraction. Clinical trials with topical SNAP-8 formulations (10 ppm) showed significant reductions in wrinkle depth at the eye contour area vs placebo at 4 and 8 weeks.
Leuprolide Acetate clinical data; Lipotec (SNAP-8 developer) clinical studies
Preclinical Safety Data
SNAP-8 has an excellent safety profile in cosmetic research. It is a short synthetic peptide with no known toxicity, irritation, or sensitization at research concentrations. No systemic effects at topical doses. Widely used in cosmetic formulations globally.
Research Dosing Protocols
From published literature — for research reference only.
Topical Serum Application
0.005–0.01% (5–10 ppm) in final formulation
Once or twice daily
Apply to expression-prone areas: forehead, glabella, crow's feet, nasolabial folds. Allow absorption before heavier moisturizers.
Stacking Guide
GHK-Cu
$50.00SNAP-8 reduces muscle contraction-driven wrinkles (dynamic lines); GHK-Cu rebuilds collagen and skin structural integrity (static lines and thickness). Together they address both causes of facial aging.
Frequently Asked Questions
What is SNAP-8?
SNAP-8 is a synthetic octapeptide (8 amino acids) developed by Lipotec. It is an analog of the N-terminal end of SNAP-25, a protein involved in acetylcholine vesicle release at neuromuscular junctions. By partially inhibiting SNAP-25, it reduces muscle contraction and the formation of expression lines.
Is SNAP-8 like Botox?
SNAP-8 works through the same mechanistic pathway as botulinum toxin — reducing acetylcholine release at the neuromuscular junction. However, it is a peptide applied topically rather than a bacterial toxin injected directly into muscle. Its effect is partial and reversible, making it a lower-intensity alternative for research on expression line reduction.
Research Disclosure: All products on this page are for laboratory research purposes only. They are not FDA-approved for human consumption, injection, or therapeutic use. Research findings cited are from preclinical and clinical studies and should not be interpreted as medical advice. Always consult a licensed healthcare provider.
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SNAP-8 10mg
$45.00